Opportunity Information: Apply for PAR 21 173
The Support for Research Excellence - First Independent Research (SuRE-First) Award (R16, Clinical Trial Not Allowed) is an NIH grant opportunity created to strengthen research capacity at U.S. colleges and universities that historically receive limited NIH funding and that educate significant numbers of students from groups underrepresented in biomedical research. The program is designed not only to fund a research project, but also to improve the local research environment and expand hands-on research opportunities for students, aligning with NIH goals around broadening participation in biomedical research (referenced in NOT-OD-20-031). In practical terms, SuRE-First is meant to help institutions build sustainable research excellence by supporting projects that can involve and train students, develop mentoring and research infrastructure, and make research more embedded in the institution's culture.
A key feature of SuRE-First is its focus on early-stage independence for faculty investigators. The award specifically supports faculty at eligible institutions who have not previously held independent external research grants. That makes it a "first independent grant" style opportunity: it is intended to help a researcher establish an externally funded research trajectory, generate publishable results, and become more competitive for future NIH or other funding. Because the funding mechanism is R16 and the notice specifies "Clinical Trial Not Allowed," proposed work must be non-clinical-trial research under NIH definitions, meaning applicants need to avoid designing studies that meet the NIH definition of a clinical trial.
Eligibility is limited to U.S.-based institutions. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and certain other organizations that fit the program's target profile. The opportunity explicitly highlights institution types that commonly serve underrepresented populations in biomedical research, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). At the same time, the solicitation clearly excludes non-U.S. participation: foreign institutions cannot apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not permitted.
From the funding opportunity data, this is an NIH discretionary grant program (FundingOpportunityNumber PAR 21 173) first created on March 18, 2021. The original closing date listed is January 7, 2024. The listed award ceiling is $125,000, indicating the maximum amount expected per award under the stated terms. The opportunity is associated with multiple CFDA numbers (now commonly referred to under the broader Assistance Listings framework), reflecting that NIH institutes and centers across many mission areas may participate or that applications may align with a range of NIH programmatic categories, spanning areas such as general biomedical research and public health-related domains.
Overall, SuRE-First is best understood as a capacity-building research grant that helps eligible, underfunded institutions support a faculty member's first externally funded independent research project while simultaneously strengthening student research engagement and the campus research ecosystem. The constraints around foreign involvement and clinical trials are strict, so proposals need to be structured as U.S.-based, non-clinical-trial research that also clearly advances the program's broader goal of cultivating sustainable research excellence and expanding meaningful research opportunities for students.Apply for PAR 21 173
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.273, 93.279, 93.286, 93.361, 93.398, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2021-03-18.
- Applicants must submit their applications by 2024-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education, Private institutions of higher education, Others.
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| Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 Clinical Trial Optional) Apply for RFA MD 21 004 Funding Number: RFA MD 21 004 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
| Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 21 155 Funding Number: PAR 21 155 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $300,000 |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) Apply for PA 21 268 Funding Number: PA 21 268 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 21 262 Funding Number: PA 21 262 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 21 259 Funding Number: PA 21 259 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 21 260 Funding Number: PA 21 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center and Database (UM1 Clinical Trial Not Allowed) Apply for RFA HG 21 037 Funding Number: RFA HG 21 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Clinical Trial Not Allowed Apply for RFA HG 21 036 Funding Number: RFA HG 21 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 21 345 Funding Number: PA 21 345 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) Apply for PAR 22 073 Funding Number: PAR 22 073 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 22 105 Funding Number: PAR 22 105 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 22 177 Funding Number: PA 22 177 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 22 178 Funding Number: PA 22 178 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 22 176 Funding Number: PA 22 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| Maternal Health Research Centers of Excellence Data Innovation and Coordinating Hub/Resource Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 23 036 Funding Number: RFA HD 23 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence Implementation Science Hub/Resource Center (U24 Clinical Trial Optional) Apply for RFA HD 23 037 Funding Number: RFA HD 23 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional) Apply for RFA HD 23 035 Funding Number: RFA HD 23 035 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $17,500,000 |
| Open Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 017 Funding Number: RFA OD 22 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Laboratory Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 016 Funding Number: RFA OD 22 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (U2C) (Clinical Trial Not Allowed) Apply for RFA OD 22 021 Funding Number: RFA OD 22 021 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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