Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed) | RFA OD 25 010

Opportunity Information: Apply for RFA OD 25 010

The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), is offering an R24 grant opportunity to support the development of broadly useful research resources for studying human health and disease. The focus is on building, improving, or thoroughly characterizing research models of human diseases and health-related biological processes, as well as creating biology-based new approach methodologies (NAMs). In addition to physical models and materials, ORIP is also interested in efforts that improve access to information produced by these models, including resources that help the wider community find, interpret, or use model-generated data more effectively. A key expectation is that the products of the project (models, NAMs, and related biological materials or information resources) will function as shared infrastructure that multiple research groups and scientific fields can use, rather than serving a single narrow line of investigation.

A central requirement is broad NIH-wide relevance. Proposed resources must be applicable to the scientific interests of at least two or more NIH Institutes or Centers (ICs). ORIP emphasizes that supported models should be relevant to diseases and biological processes that affect multiple organ systems, reflecting ORIP's cross-cutting mission as an infrastructure-focused NIH office rather than a disease-specific institute. Because of this, applications need to make a clear case for why the proposed resource is needed by the broader research community and how it will have meaningful impact across multiple disciplines. The proposal should show that the anticipated users extend beyond a single niche area, and that the resource will enable or accelerate research that aligns with priorities across multiple NIH components.

The funding announcement also draws firm boundaries around what will not be considered responsive. Projects aimed at developing a model strictly tied to one specific disease area, or that only serve a narrow slice of the biomedical research ecosystem, are not acceptable under this opportunity. Likewise, proposals that primarily support the mission of a single NIH Institute or Center, with only minimal or peripheral relevance to other ICs, are discouraged and may be rejected as nonresponsive. In practice, competitive applications will likely demonstrate multi-IC relevance in a concrete way, such as enabling research questions that span multiple physiological systems, supporting several major fields (for example immunology, metabolism, neuroscience, aging biology, or environmental health), or filling a shared methodological gap that many disease areas face.

This is an R24 mechanism and the notice specifies "Clinical Trials Not Allowed," meaning the supported work is intended to be resource-focused and preclinical or methodological rather than involving clinical trial activities. The overall aim is to create tools, models, materials, and accessible information streams that other researchers can adopt and build upon, strengthening the national biomedical research infrastructure rather than funding a traditional hypothesis-driven study centered on one disease.

Eligibility is broad for domestic applicants and includes state, county, and city or township governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education where noted); for-profit organizations (other than small businesses); small businesses; and other eligible entities as described in the NOFO. Foreign participation is explicitly limited: non-U.S. organizations are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed under this opportunity.

Key administrative details from the listing include the opportunity title "Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)," funding opportunity number RFA-OD-25-010, and CFDA number 93.351. The sponsoring agency is NIH. The opportunity is listed with an original closing date of 2028-09-28, and it anticipates making about six awards. The award ceiling is not specified in the provided summary, so applicants would need to consult the full NOFO for budget limits, project period expectations, review criteria, and other required application components.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
• This funding opportunity was created on 2025-12-05.
• Applicants must submit their applications by 2028-09-28.
• The number of recipients for this funding is limited to 6 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA OD 25 010

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