Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional) | PAR 23 245

Opportunity Information: Apply for PAR 23 245

The National Institutes of Health (NIH), through the National Library of Medicine (NLM), is offering an R01 grant opportunity titled "Personal Health Informatics for Delivering Actionable Insights to Individuals (Clinical Trial Optional)" (Funding Opportunity Number: PAR-23-245). The main goal is to push forward new informatics and data science methods that help people make sense of their own health data and translate it into practical, usable guidance. In other words, this program is centered on turning personal health information into insights that individuals can act on to better understand risks, make informed choices, and ultimately improve health outcomes.

The NOFO emphasizes advancing the science of personal health informatics by improving how personal data are collected, combined, and analyzed across sources, and how individualized risk assessments are generated and interpreted. Strong proposals will go beyond simply building a tool or model; they will also address how the results are communicated to end users in ways that are understandable, meaningful, and responsibly framed. NLM is explicitly interested in work that studies how platforms, systems, and tools should present personalized assessments, including explaining the interpretation and the limitations of those assessments so that individuals are not misled, overwhelmed, or falsely reassured.

A central theme is real-world usefulness and user involvement. Applications are expected to include end-user engaged approaches, meaning the intended users should help shape the design, functionality, and presentation of outputs. The opportunity also calls for real-world evaluation, not just technical development in isolation. The idea is to generate evidence about what works for people in practical settings, and to use those findings to inform designs that can be generalized and reused. NLM is looking for solutions that can scale, are reusable across contexts, and can serve as broadly applicable components or platforms rather than one-off prototypes that only function in a narrow environment.

This is a discretionary grant using the NIH R01 mechanism, and clinical trials are optional, so projects may include a clinical trial if it makes sense for the research questions, but they are not required. The opportunity is categorized under Education and Health activities and references CFDA numbers 93.242 and 93.879. The posted award ceiling is $250,000. The listing shows the original closing date as 2026-11-05, indicating multiple years of availability for applicants to plan and submit.

Eligibility is broad and includes many types of organizations: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The NOFO also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, Indian/Native American Tribal Governments other than federally recognized entities, and even non-domestic (non-U.S.) entities (foreign organizations). This breadth signals an interest in diverse settings, populations, and implementation contexts, including community-rooted and equity-relevant work.

Overall, this grant opportunity is aimed at research and development that makes personal health data genuinely useful to individuals by producing actionable, well-explained, and responsibly communicated insights. Competitive applications will likely combine strong informatics or data science innovation with careful attention to human factors, user-centered design, communication of uncertainty and limitations, and evaluation in real-life conditions, all while producing tools or approaches that can be generalized and scaled beyond a single study site or population.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.879.
• This funding opportunity was created on 2023-08-09.
• Applicants must submit their applications by 2026-11-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $250,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 23 245

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